Using the Clinical Question/PICOT question components, identify at least two themes which will organize the literature review .

Based on the clinical question/PICOT question components, two themes that could organize the literature review are:

1. Efficacy of pharmacotherapeutic interventions for the treatment of bipolar disorder in adults: This theme could focus on the effectiveness of different pharmacotherapeutic interventions, such as mood stabilizers, antipsychotics, and antidepressants, for the treatment of bipolar disorder in adult patients.
2. Safety considerations of pharmacotherapeutic interventions for the treatment of bipolar disorder in pediatric patients: This theme could focus on the safety considerations, such as adverse effects and drug interactions, of pharmacotherapeutic interventions used for the treatment of bipolar disorder in pediatric patients.