a) Confusion is a disease process. b) Confusion is always temporary. c) Age is a reliable predictor of confusion. d) Polypharmacy is a major contributor to confusion in older adults.

d) Polypharmacy is a major contributor to confusion in older adults.

Explanation:

Confusion is a state of mental disorientation and can occur due to a variety of reasons, including illness, medication side effects, and environmental changes. It is not a disease process, as stated in option a.

Confusion is not always temporary, as stated in option b. It can be a chronic condition, especially in individuals with dementia or other neurological conditions.

Age is not a reliable predictor of confusion, as stated in option c. Confusion can occur at any age due to various reasons.

Polypharmacy, or the use of multiple medications, is a major contributor to confusion in older adults. The use of multiple medications can lead to drug interactions, adverse drug reactions, and cognitive impairment, which can all contribute to confusion. Therefore, option d is the correct statement.